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Medical ethics and bioethics have been major emphases for the Ethics Center since it was founded. 

The center’s efforts in medical ethics and bioethics were initially led by the late Dr. Shirley Bach, Associate Director and Professor Emerita of Philosophy. Bach worked closely with the local medical community for many years, developing ethics programming and providing expert consultation. She supported the work of the Ethics Center in sponsoring biomedical ethics speakers and programs. She established two endowments to support bioethics speakers and programming.

More recently, the center has helped sponsor the interdisciplinary É«É«À² Medical Humanities Workgroup, co-founded by advisory board member Dr. Fritz Allhoff and former staff member David Charlton. The workgroup explores ethics and other humanistic dimensions of medicine through an annual conference and other activities. Allhoff, Charlton and others connected to the center also helped develop curricular content for the successful accreditation application of the É«É«À² Michigan University Homer Stryker M.D. School of Medicine.

The center has sponsored bioethics speakers on campus and at national conferences by the Association for Practical and Professional Ethics and the Society for Ethics Across the Curriculum. The center held a bioethics conference at É«É«À² Michigan University in recognition of its 30th anniversary in 2015 and a mini-conference on ethics and medical error in Chicago in 2018. Five of the submissions were published as a in the International Journal of Applied Philosophy (Vol. 32, No. 2). Other submissions were published in a special issue on medical error co-edited by Center Director Sandra L. Borden and Advisory Board member Fritz Allhoff in the Kennedy Institute of Ethics Journal (). A book co-edited by Dr. Allhoff and center Dr. Borden also grew out of the mini-conference. was published by Routledge in 2019.